Article
Intracellular FGF-2 promotes differentiation in T-47D breast cancer cells.
Biochemical and biophysical research communications - 14 Oct 2000
Korah R M, Sysounthone V, Scheff E, Wieder R
Abstract excerpt
To test the implicated role of basic fibroblast growth factor (bFGF; FGF-2) in promoting differentiation in breast cancer, we enforced the expression of FGF-2 in T-47D breast cancer cells. Expression of FGF-2 conferred an overall less malignant phenotype to T-47D cells as revealed by their reduced proliferative response, impaired capacity for anchorage-independent growth, and invasion through Matrigel. To...
Topics
- 3T3 Cells
- Animals
- Breast Neoplasms
- Cell Adhesion
- Cell Count
- Cell Differentiation
- Cell Division
- Cell Movement
- Cell Size
- Cell Transformation, Neoplastic
- Collagen
- Drug Combinations
- Fibroblast Growth Factor 2
- Gene Expression
- Humans
- Laminin
- Mice
- Phenotype