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Article

p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Woods Ignatoski Kathleen M, Grewal Navdeep K, Markwart Sonja, Livant Donna L, Ethier Stephen P

Abstract excerpt

We have previously shown that human breast cancer cells that overexpress erbB-2 are growth factor-independent. In order to test the contribution of erbB-2 to this and other transformed phenotypes without the genetic instability of cancer cells, erbB-2 was overexpressed in human mammary epithelial (HME) cells. ErbB-2-overexpressing HME cells exhibit several transformed phenotypes including cell surface alpha(4)...

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Source

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Identifiers

PMID: 12659685
DOI: 10.1016/s1476-5586(03)80004-0
PMCID: PMC1550346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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