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Article

Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells.

Molecular cancer - 18 Oct 2016

Cepeda Mario A, Pelling Jacob J H, Evered Caitlin L, Williams Karla C, Freedman Zoey, Stan Ioana, Willson Jessica A, Leong Hon S, Damjanovski Sashko

Abstract excerpt

BACKGROUND: Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease implicated in metastatic progression ostensibly due to its ability to degrade extracellular matrix (ECM) components and allow migration of cells through the basement membrane. Despite in vitro studies demonstrating this principle, this knowledge has not translated into the use of MMP inhibitors (MMPi) as effective cancer...

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Source

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Identifiers

PMID: 27756325
DOI: 10.1186/s12943-016-0547-x
PMCID: PMC5070195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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