Article
A highly invasive subpopulation of MDA-MB-231 breast cancer cells shows accelerated growth, differential chemoresistance, features of apocrine tumors and reduced tumorigenicity in vivo.
Oncotarget - 18 Oct 2016
Amaro Adriana, Angelini Giovanna, Mirisola Valentina, Esposito Alessia Isabella, Reverberi Daniele, Matis Serena, Maffei Massimo, Giaretti Walter, Viale Maurizio, Gangemi Rosaria, Emionite Laura, Astigiano Simonetta, Cilli Michele, Bachmeier Beatrice E, Killian Peter H, Albini Adriana, Pfeffer Ulrich
Abstract excerpt
The acquisition of an invasive phenotype is a prerequisite for metastasization, yet it is not clear whether or to which extent the invasive phenotype is linked to other features characteristic of metastatic cells. We selected an invasive subpopulation from the triple negative breast cancer cell line MDA-MB-231, performing repeated cycles of preparative assays of invasion through Matrigel covered membranes. The...
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