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Article

Genomic DNA analyses of spontaneous hepatocellular carcinomas in LEC rat liver using a new technique.

Oncology reports - 1 Jan 2000

Nagai H, Sugiyama T, Yoshikawa H, Kim Y S, Yeo S Y, Konishi N, Matsubara K

Abstract excerpt

An inbred rat strain, LEC (long evans cinnamon) has been used as a model of human Wilson's disease. This animal suffers from a severe type of hepatitis, the clinical manifestations of which are similar to human fulminant hepatitis for 4-5 months which is caused by accumulation of copper in the liver. The surviving rats develop chronic hepatitis, followed by the development of spontaneous hepatoma. In contrast to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10671678
DOI: 10.3892/or.7.2.315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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