Article
New mutation causing hereditary hepatitis in the laboratory rat.
The Journal of heredity - 1 Jan 2000
Yoshida M C, Masuda R, Sasaki M, Takeichi N, Kobayashi H, Dempo K, Mori M
Abstract excerpt
A new mutant causing hereditary hepatitis associated with severe jaundice has been discovered in the LEC strain of rats. Hepatitis appears suddenly in adult rats three to four months after birth. The clinical signs of hepatitis are characterized by severe jaundice, subcutaneous bleeding, oliguria, and loss of body weight. The affected rats showed a high lethality and histological changes of the liver with focal...
Topics
- Aging
- Animals
- Animals, Laboratory
- Body Weight
- Disease Models, Animal
- Female
- Genes, Recessive
- Hepatitis, Animal
- Homozygote
- Male
- Mutation
- Rats