Article
Identification of a locus for susceptibility to renal cell carcinoma in the Long-Evans Cinnamon rat.
The Journal of veterinary medical science - 1 Nov 1999
Wei K, Izumi K, Hino A, Wei S, Sasaki Y, Yamada T, Matsumoto K
Abstract excerpt
The Long-Evans Cinnamon (LEC) mutant rat shows higher incidence of renal cell carcinomas induced by a treatment with the chemical carcinogen N-diethylnitrosamine, as compared to the normal control rat. We performed the first genome-wide scan for genes responsible for susceptibility to chemically induced renal cell carcinoma in an F2 intercross obtained by mating the LEC and Fischer-344 (F344) rats. The genotype...
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