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Article

T cell specific Cxcr5 deficiency prevents rheumatoid arthritis.

Scientific reports - 21 Aug 2017

Moschovakis Georgios L, Bubke Anja, Friedrichsen Michaela, Falk Christine S, Feederle Regina, Förster Reinhold

Abstract excerpt

The chemokine receptor CXCR5 is primarily expressed on B cells and Tfh cells and facilitates their migration towards B cell follicles. In the present study we investigated the role of the CXCL13/CXCR5 axis in the pathogenesis of rheumatoid arthritis (RA) and specifically addressed the impact of CXCR5-mediated T and B cell migration in this disease. Employing collagen-induced arthritis (CIA) we identify CXCR5 as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28827539
DOI: 10.1038/s41598-017-08935-6
PMCID: PMC5567121

Genes

CXCR5
CXCL13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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