Article
Importance of B cell co-stimulation in CD4(+) T cell differentiation: X-linked agammaglobulinaemia, a human model.
Clinical and experimental immunology - 1 Jun 2011
Martini H, Enright V, Perro M, Workman S, Birmelin J, Giorda E, Quinti I, Lougaris V, Baronio M, Warnatz K, Grimbacher B
Abstract excerpt
We were interested in the question of whether the congenital lack of B cells actually had any influence on the development of the T cell compartment in patients with agammaglobulinaemia. Sixteen patients with X-linked agammaglobulinaemia (XLA) due to mutations in Btk, nine patients affected by common variable immune deficiency (CVID) with <2% of peripheral B cells and 20 healthy volunteers were enrolled. The T...
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