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Article

Oncogenic KRAS promotes malignant brain tumors in zebrafish

2 Feb 2015

Abstract excerpt

BACKGROUND: Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most devastating and difficult to treat. In this study, we evaluated zebrafish as a brain tumor model...

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PMID: 25644510
DOI: 10.1186/s12943-015-0288-2

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