Article
Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model.
Cancer research - 1 Mar 2003
Ding Hao, Shannon Patrick, Lau Nelson, Wu Xiaoli, Roncari Luba, Baldwin Rebecca L, Takebayashi Hirohide, Nagy Andras, Gutmann David H, Guha Abhijit
Abstract excerpt
A significant proportion of human malignant gliomas exhibit amplification, overexpression, or mutations of the epidermal growth factor receptor (EGFR). To define the functional role(s) of the EGFR in the pathogenesis of gliomas, we established transgenic mice that express both wild-type (wt) and mutant (EGFRvIII) EGFR molecules using the human glial fibrillary acidic protein (GFAP) promoter. Both GFAP-EGFR(wt)...
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