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Article

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis

7 Feb 2009

Abstract excerpt

Glioblastoma multiforme (GBM) is a highly lethal brain tumor for which little treatment is available. The epidermal growth factor receptor (EGFR) signaling pathway is thought to play a crucial role in GBM pathogenesis, initiating the early stages of tumor development, sustaining tumor growth, promoting infiltration, and mediating resistance to therapy. The importance of this pathway is highlighted in the fact...

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PMID: 19196966
DOI: 10.1073/pnas.0813314106

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