Article
A 4-Mb high-density single nucleotide polymorphism-based map around human APOE.
Genomics - 15 Nov 1998
Lai E, Riley J, Purvis I, Roses A
Abstract excerpt
Whole-genome association studies using single-nucleotide polymorphisms (SNPs) are the proposed method of choice for the identification of loci associated with complex diseases. In this report, we address the feasibility of generating high-density SNP maps (with <100-kb spacing). As a pilot study, we concentrated on a 4-Mb region around the human APOE locus on chromosome 19. We compared the efficiency of SNP...
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