Article
A 4-Mb high-density single nucleotide polymorphism-based map around human APOE.
Genomics - 15 Nov 1998
Lai E, Riley J, Purvis I, Roses A
Abstract excerpt
Whole-genome association studies using single-nucleotide polymorphisms (SNPs) are the proposed method of choice for the identification of loci associated with complex diseases. In this report, we address the feasibility of generating high-density SNP maps (with <100-kb spacing). As a pilot study,...
Topics
- Alleles
- Apolipoproteins E
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Chromosomes, Human, Pair 19
- Contig Mapping
- Ethnicity
- Expressed Sequence Tags
- Gene Frequency
- Humans
- Nucleotides
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Sequence Analysis, DNA
- Software