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Article

Requirement for prolonged action in the cytosol for optimal protein synthesis inhibition by diphtheria toxin.

The Journal of biological chemistry - 11 Feb 2000

Falnes P O, Ariansen S, Sandvig K, Olsnes S

Abstract excerpt

Diphtheria toxin A-fragment enters the cytosol of target cells, where it inhibits protein synthesis by catalyzing ADP-ribosylation of elongation factor 2 (EF-2). We have here analyzed toxin-induced protein synthesis inhibition in single cells by autoradiography and compared it with inhibition of protein synthesis in the whole cell culture. The data show that half-maximal protein synthesis inhibition in the whole...

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Identifiers

PMID: 10660606
DOI: 10.1074/jbc.275.6.4363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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