GTP-binding-defective forms of tissue transglutaminase trigger cell death.

doi:10.1021/bi701422h

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GTP-binding-defective forms of tissue transglutaminase trigger cell death.

Biochemistry - 25 Dec 2007

Datta Sunando, Antonyak Marc A, Cerione Richard A

Abstract excerpt

Tissue transglutaminase (TGase-2), which binds GTP and catalyzes the cross-linking of proteins (transamidation), has been implicated both in the promotion of cell death and in the protection of cells against apoptotic insults. However, a novel transcript originally identified from the brains of Alzheimer's patients, encoding a truncated form of TGase-2 (called TGase-S), shows strong apoptotic activity. TGase-S...

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GTP-binding-defective forms of tissue transglutaminase trigger cell death.

Abstract excerpt

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GTP-binding-defective forms of tissue transglutaminase trigger cell death.

Abstract excerpt

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