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Article

Endosomal proteolysis of diphtheria toxin without toxin translocation into the cytosol of rat liver in vivo.

The FEBS journal - 1 Apr 2008

El Hage Tatiana, Decottignies Paulette, Authier François

Abstract excerpt

A detailed proteolysis study of internalized diphtheria toxin (DT) within rat liver endosomes was undertaken to determine whether DT-resistant species exhibit defects in toxin endocytosis, toxin activation by cellular enzymes or toxin translocation to its cytosolic target. Following administration of a saturating dose of wild-type DT or nontoxic mutant DT (mDT) to rats, rapid endocytosis of the intact 62-kDa...

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Identifiers

PMID: 18312597
DOI: 10.1111/j.1742-4658.2008.06326.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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