Article
Modification of the reactivity of three amino-acid residues in elongation factor 2 during its binding to ribosomes and translocation.
Biochimica et biophysica acta - 6 Apr 1990
Lavergne J P, Marzouki A, Reboud A M, Reboud J P
Abstract excerpt
The accessibility of three amino acids of EF-2, located within highly conserved regions near the N- and C-terminal extremities of the molecule (the E region and the ADPR region, respectively) to modifying enzymes has been compared within nucleotide-complexed EF-2 and ribosomal complexes that mimic the pre- and posttranslocational ones: the high-affinity complex (EF-2)-nonhydrolysable GTP analog GuoPP[CH2]P...
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