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Article

Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation.

EMBO reports - 1 Dec 2002

Rodighiero Chiara, Tsai Billy, Rapoport Tom A, Lencer Wayne I

Abstract excerpt

Cholera toxin travels from the cell surface of affected mammalian cells to the endoplasmic reticulum (ER), where the A1 chain is released and retro-translocated across the ER membrane into the cytosol. We have tested whether, as in other cases, retro-translocation requires poly-ubiquitination. We show that an A1 chain mutant that lacks lysines and has a blocked N-terminus, and therefore cannot be ubiquitinated,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12446567
DOI: 10.1093/embo-reports/kvf239
PMCID: PMC1308323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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