Article
Localization of tumor suppressor gene candidates by cytogenetic and short tandem repeat analyses in tumorigenic human bronchial epithelial cells.
Carcinogenesis - 1 Feb 2000
Weaver D A, Hei T K, Hukku B, Demuth J P, Crawford E L, McRaven J A, Girgis S, Willey J C
Abstract excerpt
Radon exposure is associated with increased risk for bronchogenic carcinoma. Mutagenesis analyses have revealed that radon induces mostly multi-locus chromosome deletions. Based on these findings, it was hypothesized that deletion analysis of multiple radon-induced malignant transformants would reveal common mutations in chromosomal regions containing tumor suppressor genes responsible for malignant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.