Article
Induction of genomic instability in normal human bronchial epithelial cells by 238Pu alpha-particles.
Carcinogenesis - 1 Aug 1996
Kennedy C H, Mitchell C E, Fukushima N H, Neft R E, Lechner J F
Abstract excerpt
Pulmonary deposition of alpha-particle-emitting radon daughters is estimated to account for 10% of all lung cancer deaths in the USA. However, the nature and timing of early (preneoplastic) genetic alterations in radon-associated lung cancer are still relatively uncertain. The purpose of this inv...
Topics
- Adolescent
- Alpha Particles
- Bronchi
- Cell Division
- Cells, Cultured
- DNA, Satellite
- Dose-Response Relationship, Radiation
- Epithelial Cells
- Epithelium
- Humans
- Male
- Mutation
- Polonium