Article
Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes.
Advances in cancer research - 1 Jan 1997
Kok K, Naylor S L, Buys C H
Abstract excerpt
The concept that cells can become malignant upon the elimination of parts of chromosomes inhibiting cell division dates back to Boveri in 1914. Deletions occurring in tumor cells are therefore considered a first indication of possible locations of tumor suppressor gene. Approaches used to localize and identify the paradigm of tumor suppressors, RB1, have also been applied to localize tumor suppressor genes on 3p,...
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