Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes.

doi:10.1073/pnas.91.9.3759

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Article

Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes.

Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 1994

Wiseman R W, Cochran C, Dietrich W, Lander E S, Söderkvist P

Abstract excerpt

To identify the potential involvement of tumor-suppressor gene inactivation during neoplastic development in B6C3F1 mice, genetic losses were determined from allelotypes of butadiene-induced lung and mammary adenocarcinomas. By using length polymorphisms in restriction fragments and simple sequen...

Topics

Adenocarcinoma
Alleles
Animals
Base Sequence
Butadienes
Chromosome Mapping
DNA Primers
DNA, Neoplasm
Female
Genes, Retinoblastoma
Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Lung Neoplasms

Male

Mammary Neoplasms, Experimental

Mice

Mice, Inbred C3H

Source

Open in PubMed Open full text

Identifiers

PMID: 8170984
DOI: 10.1073/pnas.91.9.3759
PMCID: PMC43661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8170984-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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