Article
Correlated mutagenesis of bcl2 and hprt loci in blood lymphocytes.
Environmental and molecular mutagenesis - 1 Jan 1997
Liu Y, Cortopassi G, Steingrimsdottir H, Waugh A P, Beare D M, Green M H, Robinson D R, Cole J
Abstract excerpt
In vivo measurement of human somatic mutations may be a valuable biodosimeter of exposure to carcinogens and of cancer risk. We have surveyed translocations at the bcl2 locus in B lymphocytes, and mutations at hprt in T lymphocytes, in 120 individuals with varying exposure to radon and cigarette smoke. bcl2 t(14:18) translocation is the commonest chromosomal alteration observed in non-Hodgkins lymphoma (NHL). We...
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