Article
Molecular follow-up of preneoplastic lesions in bronchial epithelium of former Chernobyl clean-up workers.
Oncogene - 4 Apr 2002
Chizhikov Victor, Chikina Svetlana, Gasparian Alexander, Zborovskaya Irina, Steshina Ekaterina, Ungiadze Guram, Samsonova Maria, Chernyaev Andrei, Chuchalin Alexander, Tatosyan Alexander
Abstract excerpt
Ionizing radiation is a potent lung carcinogen, but the precise molecular damage associated with it is still unknown. In this study we investigated cancer-related molecular abnormalities including K-ras (codon 12) mutation, p16(INK4A) promoter hypermethylation and microsatellite alterations at seven chromosomal regions in successive biopsies obtained from former Chernobyl cleanup workers in comparison with...
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