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Article

TGFβ-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism

1 Mar 2018

Abstract excerpt

The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A persisting optic fissure, coloboma, is a major cause for blindness in children. Although many genes have been linked to coloboma, the process of optic fissure fusion is still little appreciated, especially on a molecular level. We identified a coloboma in mice with a targeted inactivation of...

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PMID: 29593116
DOI: 10.1098/rsob.170134

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