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Article

Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration.

Life science alliance - 1 Jan 2022

Lin Shuhao, Hirayama Daiki, Maryu Gembu, Matsuda Kimiya, Hino Naoya, Deguchi Eriko, Aoki Kazuhiro, Iwamoto Ryo, Terai Kenta, Matsuda Michiyuki

Abstract excerpt

Epidermal growth factor receptor (EGFR) plays a pivotal role in collective cell migration by mediating cell-to-cell propagation of extracellular signal-regulated kinase (ERK) activation. Here, we aimed to determine which EGFR ligands mediate the ERK activation waves. We found that epidermal growth factor (EGF)-deficient cells exhibited lower basal ERK activity than the cells deficient in heparin-binding EGF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34667080
DOI: 10.26508/lsa.202101206
PMCID: PMC8548211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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