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Article

TGFalpha is required for full expression of the transformed growth phenotype of NIH 3T3 cells overexpressing ornithine decarboxylase.

Carcinogenesis - 1 Apr 2000

Geng H, Naylor P H, Dosescu J, Skunca M, Majumdar A P, Moshier J A

Abstract excerpt

Ornithine decarboxylase (ODC) overexpressed from a heterologous promoter drives the tumorigenic transformation of NIH 3T3 cells and provides a model to investigate the underlying molecular mechanisms. These transformed cells, designated NODC cells, exhibit elevated levels of epidermal growth factor receptor (EGFR) tyrosine kinase (Tyr-k) activity relative to control transfected cells and inhibition of EGFR Tyr-k...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10753187
DOI: 10.1093/carcin/21.4.567

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TGFalpha is required for full expression of the transformed growth phenotype of NIH 3T3 cells overexpressing ornithine decarboxylase.PMID 10753187Read ↗

Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.Semantic proximity Read ↗

Ornithine decarboxylase overexpression in mouse 10T1/2 fibroblasts: cellular transformation and invasion.Semantic proximity Read ↗

K-FGF mediated transformation and induction of metastatic potential involves altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression--role in cellular invasion.Semantic proximity Read ↗

Overexpression of activated neu/erbB2 initiates immortalization and malignant transformation of immature Schwann cells in vitro.Semantic proximity Read ↗

Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor.Semantic proximity Read ↗

Transcriptional and translational control of ornithine decarboxylase during Ras transformation.Semantic proximity Read ↗

Reversible regulation of the transformed phenotype of ornithine decarboxylase- and ras-overexpressing cells by dominant-negative mutants of c-Jun.Semantic proximity Read ↗

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Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation.Semantic proximity Read ↗

Resistance to transformation by insertionally activated c-erbB is a dominant phenotype in fibroblasts.Semantic proximity Read ↗

Altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression and regulation in mouse fibroblasts transformed with oncogenes or constitutively active Mitogen-Activated Protein (MAP) kinase kinase.Semantic proximity Read ↗

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