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Article

APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus.

Genes & development - 1 Jan 2008

Visintin Clara, Tomson Brett N, Rahal Rami, Paulson Jennifer, Cohen Michael, Taunton Jack, Amon Angelika, Visintin Rosella

Abstract excerpt

In the budding yeast Saccharomyces cerevisiae, the protein phosphatase Cdc14 triggers exit from mitosis by promoting the inactivation of cyclin-dependent kinases (CDKs). Cdc14's activity is controlled by Cfi1/Net1, which holds and inhibits the phosphatase in the nucleolus from G1 until metaphase. During anaphase, two regulatory networks, the Cdc14 Early Anaphase Release (FEAR) network and the Mitotic Exit Network...

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Identifiers

PMID: 18172166
DOI: 10.1101/gad.1601308
PMCID: PMC2151016

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus.PMID 18172166Read ↗

The role of the polo kinase Cdc5 in controlling Cdc14 localization.Semantic proximity Read ↗

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus.Semantic proximity Read ↗

Cdc14 Early Anaphase Release, FEAR, Is Limited to the Nucleus and Dispensable for Efficient Mitotic Exit.Semantic proximity Read ↗

The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.Semantic proximity Read ↗

Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast.Semantic proximity Read ↗

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.Semantic proximity Read ↗

Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.Semantic proximity Read ↗

Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.Semantic proximity Read ↗

Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network.Semantic proximity Read ↗

DNA damage checkpoints inhibit mitotic exit by two different mechanisms.Semantic proximity Read ↗

Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.Semantic proximity Read ↗

Crm1-mediated nuclear export of Cdc14 is required for the completion of cytokinesis in budding yeast.Semantic proximity Read ↗

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