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Article

Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p.

The Journal of cell biology - 9 Jul 2001

Huang J N, Park I, Ellingson E, Littlepage L E, Pellman D

Abstract excerpt

Cell cycle progression is driven by waves of cyclin expression coupled with regulated protein degradation. An essential step for initiating mitosis is the inactivation of proteolysis mediated by the anaphase-promoting complex/cyclosome (APC/C) bound to its regulator Cdh1p/Hct1p. Yeast APC(Cdh1) w...

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Share to Anaphase-Promoting Complex-Cyclosome
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Source

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Identifiers

PMID: 11448992
DOI: 10.1083/jcb.200102007
PMCID: PMC2196868

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11448992-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p.PMID 11448992Read ↗

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.Semantic proximity Read ↗

Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from MitosisSemantic proximity Read ↗

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.Semantic proximity Read ↗

Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.Semantic proximity Read ↗

Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cells.Semantic proximity Read ↗

p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress.Semantic proximity Read ↗

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.Semantic proximity Read ↗

Mitotic regulation of the APC activator proteins CDC20 and CDH1.Semantic proximity Read ↗

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.Semantic proximity Read ↗

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.Semantic proximity Read ↗

Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.Semantic proximity Read ↗

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