Article
Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.
The Journal of pathology - 1 May 2017
De Smet Frederik, Saiz Rubio Mirian, Hompes Daphne, Naus Evelyne, De Baets Greet, Langenberg Tobias, Hipp Mark S, Houben Bert, Claes Filip, Charbonneau Sarah, Delgado Blanco Javier, Plaisance Stephane, Ramkissoon Shakti, Ramkissoon Lori, Simons Colinda, van den Brandt Piet, Weijenberg Matty, Van England Manon, Lambrechts Sandrina, Amant Frederic, D'Hoore André, Ligon Keith L, Sagaert Xavier, Schymkowitz Joost, Rousseau Frederic
Abstract excerpt
Although p53 protein aggregates have been observed in cancer cell lines and tumour tissue, their impact in cancer remains largely unknown. Here, we extensively screened for p53 aggregation phenotypes in tumour biopsies, and identified nuclear inclusion bodies (nIBs) of transcriptionally inactive mutant or wild-type p53 as the most frequent aggregation-like phenotype across six different cancer types. p53-positive...
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