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Article

Cytoplasmic localization of Mdm2 in cells expressing mutated NPM is mediated by p53.

The FEBS journal - 1 Sept 2023

Strachotová Dita, Holoubek Aleš, Wolfová Kateřina, Brodská Barbora, Heřman Petr

Abstract excerpt

Specific C-terminal nucleophosmin (NPM) mutations are related to the acute myeloid leukaemia and cause mistargeting of mutated NPM (NPMmut) to the cytoplasm. Consequently, multiple NPM-interacting partners, e.g., the tumour suppressor p53, become also mislocalized. We found that ubiquitin ligase Mdm2 mislocalizes to the cytoplasm in the presence of NPMmut as well. Since p53 interacts with Mdm2, we searched for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Identifiers

PMID: 37119456
DOI: 10.1111/febs.16810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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