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The tumor suppressor HNRNPK induces p53-dependent nucleolar stress to drive ribosomopathies

8 May 2025

Abstract excerpt

The nucleolus is a membraneless organelle and an excellent stress sensor. Any changes in its architecture or composition lead to nucleolar stress, resulting in cell cycle arrest and interruption of ribosomal activity, critical factors in aging and cancer. In this study, we identified and described the pivotal role of the RNA-binding protein HNRNPK in ribosome and nucleolar dynamics. We developed an in vitro model...

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PMID: 40338663
DOI: 10.1172/jci183697

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