Article
Quaking*shiverer double-mutant mice survive for at least 100 days with no CNS myelin.
Developmental neuroscience - 1 Jan 1999
Wolf M K, Nunnari J N, Billings-Gagliardi S
Abstract excerpt
Mice expressing mutations that produce CNS hypomyelination often die prematurely: the more severe the hypomyelination, the shorter the life span. However, we have previously described jimpy-msd mice that survive twice as long as usual; although they acquire significantly increased amounts of myelin, they still succumb long before their unaffected littermates. This result contradicts any postulated causal...
Topics
- Animals
- Central Nervous System
- Central Nervous System Diseases
- Genotype
- Longevity
- Mice
- Mice, Neurologic Mutants
- Mice, Quaking
- Microscopy, Electron
- Myelin Sheath
- Nerve Fibers, Myelinated
- Phenotype
- Survival Analysis