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Article

Evidence that CNS hypomyelination does not cause death of jimpy-msd mutant mice.

Developmental neuroscience - 1 Jan 1999

Billings-Gagliardi S, Nunnari J N, Nadon N L, Wolf M K

Abstract excerpt

Mice expressing three of the proteolipid protein (Plp) mutations in the mouse (jimpy, jimpy-msd, and jimpy-4J) all have a severe deficiency of CNS myelin and oligodendrocytes (OLs), and die sometime in their 4th postnatal week. The prevailing view has been that the animals' shortened life span and lack of myelin are causally related. Here we describe the survival of jimpy-msd males for as long as postnatal day...

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Identifiers

PMID: 10640865
DOI: 10.1159/000017414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Evidence that CNS hypomyelination does not cause death of jimpy-msd mutant mice.PMID 10640865Read ↗

Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse.Semantic proximity Read ↗

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.Semantic proximity Read ↗

The early phenotype associated with the jimpy mutation of the proteolipid protein gene.Semantic proximity Read ↗

Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse.Semantic proximity Read ↗

Jimpy-4J mouse has a missense mutation in exon 2 of the Plp gene.Semantic proximity Read ↗

Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease.Semantic proximity Read ↗

A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.Semantic proximity Read ↗

Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice.Semantic proximity Read ↗

Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene.Semantic proximity Read ↗

Oligodendrocyte development and differentiation in the rumpshaker mutation.Semantic proximity Read ↗

Dispensable regulation of brain development and myelination by the immune-related protein Serpina3nSemantic proximity Read ↗

Myelination in the absence of galactolipids and proteolipid proteins.Semantic proximity Read ↗

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