Article
A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2005
Noveroske Janice K, Hardy Rebecca, Dapper Jason D, Vogel Hannes, Justice Monica J
Abstract excerpt
The mutant allelic series of the mouse quaking gene consists of the spontaneous quaking(viable) (qk(v)) allele, which is homozygous viable with a dysmyelination phenotype, and four ENU-induced alleles (qk(kt 1), qk(k2), qk(kt3/4), and qk(l-1)), which are homozygous embryonic lethal. Here we report the isolation of qk(e5), the first ENU-induced viable allele of quaking. Unlike qk(v)/qk(v), qk(e5)/qk(e5) animals...
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