Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice.

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Article

Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jul 2000

Uschkureit T, Sporkel O, Stracke J, Bussow H, Stoffel W

Abstract excerpt

Double (plp-/-mag-/-) and triple (plp-/-mbp-/-mag-/-) null-allelic mouse lines deficient in proteolipid protein (PLP), myelin-associated glycoprotein (MAG), and myelin basic protein (MBP) were generated and characterized genetically, biochemically, and morphologically including their behavioral capacities. The plp-/-mag-/- mutant develops a rapidly progressing axon degeneration in CNS with severe cognitive and...

Topics

Animals
Axons
Behavior, Animal
Central Nervous System
Demyelinating Diseases
Gene Expression Regulation
Genotype
Membrane Lipids
Mice
Mice, Neurologic Mutants
Myelin Basic Protein
Myelin Proteolipid Protein
Myelin Sheath

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelin-Associated Glycoprotein

Neural Conduction

Peripheral Nerves

Phenotype

Transcription, Genetic

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Identifiers

PMID: 10884306
PMCID: PMC6772331

Genes

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