6-Thioguanine resistant T-lymphocyte determination as a possible indicator of human ionizing radiation exposure.

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Article

6-Thioguanine resistant T-lymphocyte determination as a possible indicator of human ionizing radiation exposure.

Boletin de estudios medicos y biologicos - 1 Jan 2000

Ostrosky-Wegman P, Montero R, Cortinas de Nava C, Hurtado F

Abstract excerpt

We used the autoradiographic assay to assess human in vivo somatic cell gene mutation at the hypoxanthine guanine phosphoribosyl transferase (hgprt) locus in T-lymphocytes. Cells able to incorporate tritiated thymidine in vitro in 6-thioguanine containing short-term cultures were enumerated in order to determine 6-thioguanine resistant (TGr) variant frequencies in cryopreserved lymphocytes from control...

Topics

Accidents
Adolescent
Adult
Cells, Cultured
Cobalt Radioisotopes
Drug Resistance
Female
Genes
Humans
Hypoxanthine Phosphoribosyltransferase
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mexico

Middle Aged

Mutation

Radiation Monitoring

T-Lymphocytes

Thioguanine

Source

Open in PubMed

Identifiers

PMID: 2633789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2633789-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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