Article
Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research - 1 Jan 2007
Ivanov Ivaylo P, Atkins John F
Abstract excerpt
The protein antizyme is a negative regulator of intracellular polyamine levels. Ribosomes synthesizing antizyme start in one ORF and at the codon 5' adjacent to its stop codon, shift +1 to a second and partially overlapping ORF which encodes most of the protein. The ribosomal frameshifting is a sensor and effector of an autoregulatory circuit which is conserved in animals, fungi and protists. Stimulatory signals...
Topics
- 3' Untranslated Regions
- Amino Acid Sequence
- Animals
- Base Sequence
- Conserved Sequence
- Frameshifting, Ribosomal
- Fungal Proteins
- Genetic Variation
- Humans
- Molecular Sequence Data
- Proteins
- Protozoan Proteins
- RNA, Messenger