Article
A new model for phenotypic suppression of frameshift mutations by mutant tRNAs.
Molecular cell - 1 Mar 1998
Qian Q, Li J N, Zhao H, Hagervall T G, Farabaugh P J, Björk G R
Abstract excerpt
According to the prevailing model, frameshift-suppressing tRNAs with an extra nucleotide in the anticodon loop suppress +1 frameshift mutations by recognizing a four-base codon and promoting quadruplet translocation. We present three sets of experiments that suggest a general alternative to this model. First, base modification should actually block such a four-base interaction by two classical frameshift...
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