Article
A new model for phenotypic suppression of frameshift mutations by mutant tRNAs.
Molecular cell - 1 Mar 1998
Qian Q, Li J N, Zhao H, Hagervall T G, Farabaugh P J, Björk G R
Abstract excerpt
According to the prevailing model, frameshift-suppressing tRNAs with an extra nucleotide in the anticodon loop suppress +1 frameshift mutations by recognizing a four-base codon and promoting quadruplet translocation. We present three sets of experiments that suggest a general alternative to this...
Topics
- Anticodon
- DNA Primers
- Frameshift Mutation
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Fungal
- Guanosine
- Nucleic Acid Conformation
- Phenotype
- Protein Biosynthesis
- RNA, Messenger
- RNA, Transfer
- Saccharomyces cerevisiae
- Salmonella typhimurium