Article
The cation channel mucolipin-1 is a bifunctional protein that facilitates membrane remodeling via its serine lipase domain.
Experimental cell research - 1 Apr 2011
LaPlante Janice M, Falardeau John L, Brown Edward M, Slaugenhaupt Susan A, Vassilev Peter M
Abstract excerpt
Phospholipase modulators have been shown to affect the topology of lipid bilayers and the formation of tubulo-vesicular structures, but the specific endogenous phospholipases involved have yet to be identified. Here we show that TRPML1 (MLN1), a Ca(2+)-permeable channel, contributes to membrane remodeling through a serine lipase consensus domain, and thus represents a novel type of bifunctional protein....
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