Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

L30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes.

Biochemistry - 8 Nov 2016

Himes Ryan D, Smolin Nikolai, Kukol Andreas, Bossuyt Julie, Bers Donald M, Robia Seth L

Abstract excerpt

To determine if mutations introduced into phospholemman (PLM) could increase the level of PLM-Na,K-ATPase (NKA) binding, we performed scanning mutagenesis of the transmembrane domain of PLM and measured Förster resonance energy transfer (FRET) between each mutant and NKA. We observed an increased level of binding to NKA for several PLM mutants compared to that of the wild type (WT), including L27A, L30A, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Fluorescence Resonance Energy Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Molecular Dynamics Simulation

Share to Mutation

Share to Myocytes, Cardiac

Share to Phosphoproteins

Share to Rabbits

Source

Open in PubMed Open full text

Identifiers

PMID: 27718550
DOI: 10.1021/acs.biochem.6b00633
PMCID: PMC5148645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

L30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes.PMID 27718550Read ↗

Impact of phosphomimetic and non-phosphorylatable mutations of phospholemman on L-type calcium channels gating in HEK 293T cells.Semantic proximity Read ↗

Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy.Semantic proximity Read ↗

A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia.Semantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and humanSemantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.Semantic proximity Read ↗

The phospholamban R14del generates pathogenic aggregates by impairing autophagosome-lysosome fusion.Semantic proximity Read ↗

Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman.Semantic proximity Read ↗

A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Semantic proximity Read ↗

Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure.Semantic proximity Read ↗

Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMsSemantic proximity Read ↗

Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels.Semantic proximity Read ↗

Phospholemman inhibition of the cardiac Na+/Ca2+ exchanger. Role of phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.