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Article

Impact of phosphomimetic and non-phosphorylatable mutations of phospholemman on L-type calcium channels gating in HEK 293T cells.

Journal of cellular and molecular medicine - 1 Mar 2015

Guo Kai, Wang Yue-Peng, Zhou Zhi-Wen, Jiang Yi-Bo, Li Wei, Chen Xiao-Meng, Li Yi-Gang

Abstract excerpt

BACKGROUND: Phospholemman (PLM) is an important phosphorylation substrate for protein kinases A and C in the heart. Until now, the association between PLM phosphorylation status and L-type calcium channels (LTCCs) gating has not been fully understood. We investigated the kinetics of LTCCs in HEK 293T cells expressing phosphomimetic or nonphosphorylatable PLM mutants. METHODS: The LTCCs gating was measured in HEK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25656605
DOI: 10.1111/jcmm.12484
PMCID: PMC4369820

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