Article
Involvement of CYP2D6 activity in the N-oxidation of procainamide in man.
Pharmacogenetics - 1 Dec 1999
Lessard E, Hamelin B A, Labbé L, O'Hara G, Bélanger P M, Turgeon J
Abstract excerpt
Occurrence of a lupus-like syndrome in a significant number of patients treated with procainamide has limited the clinical use of this antiarrhythmic drug. In-vitro studies conducted in our laboratory have demonstrated that CYP2D6 is the major cytochrome P450 isozyme involved in the formation of N-hydroxyprocainamide, a metabolite potentially involved in the drug-induced lupus erythematosus syndrome observed with...
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