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Article

Acetylation of dapsone by human whole blood.

International journal of clinical pharmacology, therapy, and toxicology - 1 Jan 1993

Irshaid Y M, al-Hadidi H F, Abuirjeie M A, Rawashdeh N M, Gharaibeh N S

Abstract excerpt

We studied the acetylation of dapsone (DDS) in vitro by whole blood taken from subjects with known acetylator phenotype. The acetylation of DDS by whole blood was both incubation time- and DDS concentration-dependent. Thus, it is highly recommended to separate plasma immediately after blood withdrawal during acetylation phenotyping using DDS. para-aminobenzoic acid (PABA) substantially inhibited the acetylation...

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Identifiers

PMID: 8444513

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