Article
Genetically determined stereoselective excretion of encainide in humans and electrophysiologic effects of its enantiomers in canine cardiac Purkinje fibers.
Clinical pharmacology and therapeutics - 1 May 1991
Turgeon J, Funck-Brentano C, Gray H T, Pavlou H N, Prakash C, Blair I A, Roden D M
Abstract excerpt
Encainide metabolism is mediated by the polymorphically distributed cytochrome P450IID6, which displays stereoselectivity for some substrates. In this study we found that urinary recovery during steady-state encainide in three poor metabolizers was high (49% to 80%), consisted mainly of unchanged...
Topics
- Action Potentials
- Anilides
- Animals
- Anti-Arrhythmia Agents
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Dogs
- Drug Evaluation, Preclinical
- Drug Interactions
- Encainide
- Phenotype
- Purkinje Fibers
- Quinidine
- Stereoisomerism