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Article

All-trans-retinoic acid modulation of drug-metabolizing enzyme activities: investigation with selective metabolic drug probes.

Cancer chemotherapy and pharmacology - 1 Jan 1998

Adedoyin A, Stiff D D, Smith D C, Romkes M, Bahnson R C, Day R, Hofacker J, Branch R A, Trump D L

Abstract excerpt

PURPOSE: All-trans-retinoic acid (ATRA) is a retinoid analogue that has been shown to be effective in acute promyelocytic leukemia. It is currently being investigated for efficacy in the treatment and prevention of various types of cancer. One of the factors limiting its use is the observed increase in ATRA clearance and elimination which occurs shortly after treatment is started, leading to reduced levels of...

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Source

Identifiers

PMID: 9443626
DOI: 10.1007/s002800050719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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