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Article

Hypomorphic bimA(APC3) alleles cause errors in chromosome metabolism that activate the DNA damage checkpoint blocking cytokinesis in Aspergillus nidulans.

Genetics - 1 Jan 2000

Wolkow T D, Mirabito P M, Venkatram S, Hamer J E

Abstract excerpt

The Aspergillus nidulans sepI(+) gene has been implicated in the coordination of septation with nuclear division and cell growth. We find that the temperature-sensitive (ts) sepI1 mutation represents a novel allele of bimA(APC3), which encodes a conserved component of the anaphase-promoting complex/cyclosome (APC/C). We have characterized the septation, nuclear division, cell-cycle checkpoint defects, and DNA...

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Source

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Identifiers

PMID: 10628978
DOI: 10.1093/genetics/154.1.167
PMCID: PMC1460891

Genes

APC

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Hypomorphic bimA(APC3) alleles cause errors in chromosome metabolism that activate the DNA damage checkpoint blocking cytokinesis in Aspergillus nidulans.PMID 10628978Read ↗

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