Article
The bimB3 mutation of Aspergillus nidulans uncouples DNA replication from the completion of mitosis.
The Journal of biological chemistry - 5 Aug 1992
May G S, McGoldrick C A, Holt C L, Denison S H
Abstract excerpt
A conditionally lethal mutation in the bimB gene of Aspergillus nidulans disrupts the normal regulatory patterns associated with mitotic events. This results in DNA replication in the absence of the completion of mitosis in the mutant at restrictive temperature. This defect yields large polyploid nuclei after several hours at restrictive temperature. The bimB gene has been cloned by genetic mapping and chromosome...
Topics
- Amino Acid Sequence
- Aspergillus nidulans
- Base Sequence
- Benomyl
- Cell Nucleus
- Cloning, Molecular
- DNA Replication
- Fluorescent Dyes
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Indoles