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Article

The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.

Journal of cell science - 1 Nov 1995

James S W, Mirabito P M, Scacheri P C, Morris N R

Abstract excerpt

The bimE (blocked-in-mitosis) gene appears to function as a negative mitotic regulator because the recessive bimE7 mutation can override certain interphase-arresting treatments and mutations, causing abnormal induction of mitosis. We have further investigated the role of bimE in cell cycle checkpoint control by: (1) coordinately measuring mitotic induction and DNA content of bimE7 mutant cells; and (2) analyzing...

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Identifiers

PMID: 8586660
DOI: 10.1242/jcs.108.11.3485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.PMID 8586660Read ↗

A negative regulator of mitosis in Aspergillus is a putative membrane-spanning protein.Semantic proximity Read ↗

Mitotic regulation in Aspergillus nidulans.Semantic proximity Read ↗

bimA encodes a member of the tetratricopeptide repeat family of proteins and is required for the completion of mitosis in Aspergillus nidulans.Semantic proximity Read ↗

Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint.Semantic proximity Read ↗

Mitotic catastrophe is the mechanism of lethality for mutations that confer mutagen sensitivity in Aspergillus nidulans.Semantic proximity Read ↗

BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function.Semantic proximity Read ↗

Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.Semantic proximity Read ↗

Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans.Semantic proximity Read ↗

Mutation in the bimD gene of Aspergillus nidulans confers a conditional mitotic block and sensitivity to DNA damaging agents.Semantic proximity Read ↗

The bimB3 mutation of Aspergillus nidulans uncouples DNA replication from the completion of mitosis.Semantic proximity Read ↗

Identification of BIME as a subunit of the anaphase-promoting complex.Semantic proximity Read ↗

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.Semantic proximity Read ↗

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