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Article

Different roles of the Mre11 complex in the DNA damage response in Aspergillus nidulans.

Molecular microbiology - 1 Jun 2003

Semighini Camile P, von Zeska Kress Fagundes Márcia Regina, Ferreira Joseane Cristina, Pascon Renata Castiglioni, de Souza Goldman Maria Helena, Goldman Gustavo Henrique

Abstract excerpt

The Mre11-Rad50-Nbs1 protein complex has emerged as a central player in the cellular DNA damage response. Mutations in scaANBS1, which encodes the apparent homologue of human Nbs1 in Aspergillus nidulans, inhibit growth in the presence of the anti-topoisomerase I drug camptothecin. We have used the scaANBS1 cDNA as a bait in a yeast two-hybrid screening and report the identification of the A. nidulans Mre11...

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PMID: 12791148
DOI: 10.1046/j.1365-2958.2003.03539.x

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